Cross the American continent from north to south and discover cultures whose lives were completely different from those of Winnetou and Nscho-tschi.

Taking up approximately 130 m² the exhibition presents the varied lifestyles of American indigenous peoples from the pre-Columbian period to the 19th century. Some 220 objects including ritual implements, works of art, clothing and pottery offer an account of everyday Indian life. They attest to both peaceful and violent encounters between American Indians and Europeans and also outline the consequences these encounters had on the indigenous tribes. In an objective manner the exhibition illustrates the variety of lifestyles and different cultures of the indigenous peoples of North America.

Besides a bison cloak of Mandan Chief Mato Topé, visitors can marvel at moccassins and a peace pipe that once belonged to Hunkpapa Chief Sitting Bull (Tatanka Yotanka). The pictures by Karl Bodmer show the 'Wild West' like it really was. Today they are some of the most important pieces of evidence relating to these past cultures.