The design approach for the Pre - Columbian Art galleries offers visitors an introduction to the culture and history of ancient Mexico: its geographical framework, the main features of the historical process, their religious thought, the depiction of the human figure and its expression, economic life, work and social relationships, forms of writing, artistic expressions, and the cult of death.

In the galleries pieces from different cultures, eras, formats, and materials coexist; its richness shows the plurality of techniques implemented by the ancient cultures of the regions of Mexico; from carvings in stone and bone, castings in gold and other metals to ceramics and fragments of mural paintings, that as a whole, allow us to understand some characteristics of Mesoamerican civilization from 1200 BCE to 1500 CE.

More than 500 artistic, ceremonial, sumptuary, and funerary objects from the West of Mexico, Balsas basin, and different sites in the valley of Mexico such as Tlatilco, Teotihuacan, Tula, and Tenochtitlan are exhibited. Pieces from central Veracruz, the Usumacinta basin, Campeche, the Valley of Oaxaca and other areas are also on display. These objects represent the Olmec, Huastec, Maya, Teotihuacan, Shaft Tombs, Nahua, Mezcala, Zapotec and Tajín cultures, among others.

This large repertoire allows us to observe some characteristics of various civilizations as a whole, gathered in seven thematical galleries and a documentation center.